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The ultimate is no joke either, you do have to deal with Wrenn and Six else you are just going to eat endless Lightning Bolts from the bin and die to it

I covered a wide selection of strong replacements for this in my Replacements for Commander Staples article, to make sure you can get your hands on a good mass removal spell

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Most white removal either destroys or exiles, and it has access to the widest array of mass removal

Since many Commander decks take advantage of nonbasic lands, it's not uncommon for Ruination to hit most, if not all the lands on the battlefield