Normally four drops need to do an awful lot or something very specific for you to want to play them
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You could make this deck work with the Poipole line, the Ekans line, the Alolan Grimer line (with the Promo A-Grimer card), or the Koffing line with a bit of tweaking, as long as youre running Nihilego and you can Poison your opponent
Mostly just don't bother trying to do that though is better advice
Desynchronization An instant speed board wipe is always welcome, even one as limited as Desynchronization, which could actually whiff in an EDH game with the proliferating number of legendary creatures out there