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Formula: C16H31N2O8P
CAS Number: 1375105-96-6
2 nM) in inhibiting isoproterenol-induced cAMP production in HEK-293 cells
MEK162 was orally dosed to mice at 3-30 mg/kg once per day
Hordenine inhibits the activity of PDK3
PI-3065 Catalog No.:M8668-10 Formula: C16H31N2O8PPI3065 is a p110 isoform of phosphoinositide 3 OH kinase (PI(3)K) inhibitor. Inhibitors against the p110 isoform of phosphoinositide 3 OH kinase (PI(3)K) have shown remarkable therapeutic efficacy in some human leukaemias. As p110 is primarily expressed in leukocytes, drugs against p110 have not been considered for the treatment of solid tumours. p110 inactivation in regulatory T cells unleashes CD8(+) cytotoxic T cells and induces tumour regression.
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