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Chapurlat RD
Chemical Name: 1-hydroxynaphthalene-2-carboxylic acid
(2014) Cell Rep
Chemical Name: N-[5-({2-cyclopropaneamidoimidazo[1
SQ-11725 D9
Bay 60-7550 - CAS# 439083-90-6 Size:Solid 10 mg Chapurlat RDBAY 60 7550 is a potent PDE2 inhibitor with IC50 values of 2. 0 nM (bovine) and 4. 7 nM (human). BAY 60 7550 antagonizes oxidative stress induced anxiety like behavioral effects in mice by increasing cGMP signaling. Phosphodiesterases (PDEs) are key regulatory enzymes of intracellular cAMP cGMP levels. These second messengers play important regulatory roles in controlling steroidogenesis in the adrenal. Disruption of PDEs has been associated with a
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